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In cartilage research, a 2015 study in a collagenase-induced knee osteoarthritis rabbit model showed that combined AOD-9604 and hyaluronic acid injections were significantly more effective than either treatment alone, with treated groups showing lower gross morphological and histopathological scores

Mild soreness or redness at the injection site can occur, but usually resolves quickly

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Furthermore, the combination of these fat-loss agents with muscle-preserving peptides like IGF-1LR3 or MGF (Mechano Growth Factor) is an active area of investigation for total body recomposition research