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Immune inflammatory dysregulation and intestinal microbial imbalance in RA are confirmed to be associated with ferroptosis

Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

This protective effect was attributed to an increased abundance of Lactobacillaceae and Lachnospirillaceae and a decreased abundance of Prevotella and Desulfovibrionaceae in the gut

Downregulation of SLC7A11 disrupts cysteine metabolism, leading to decreased intracellular cystine and GSH levels, impairing GPX4 activity and triggering lipid peroxide accumulation and ferroptosis (79,81,82)