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doi: 10.3390/cancers13143541 95 GuccioneERichardS

Pharmaceuticals 16(2):301

Altogether, our findings suggest that IGF1R depletion in the lung TME of IGF1R-deficient mice delays lung metastasis implantation and progression by reducing the presence of blood vessels, fibroblasts, TAMs and FOXP3 + TILs, as well as by increasing the amount of infiltrating CD4 + and CD8 + T cells (Fig