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Acknowledgements Authors are grateful to Panjab University, Chandigarh, India for facilities

Previous studies have reported that GPX4 regulates neutrophil survival and inflammation by limiting ferroptosis (25) In addition, GPX4, together with vitamin E, protects hematopoietic stem and progenitor cells from lipid peroxidation, thereby maintaining white blood cell homeostasis (34)

However, when ALOX12 was depleted, the expression of p53 and SLC7A11 was not affected [19]

The activation of AHR caused the upregulation of GLP-1 and IL-22 at proteins and mRNA levels, decreased systemic LPS, improved gut barrier function, activated the hepatic STAT3/IL-22R/peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) and pancreatic GLP-1R/p-CREB signaling pathways, and improved lipid metabolism and insulin resistance