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84 , 89 , 93 Hyperlactacidemia and an increased lactate/pyruvate ratio may result from several inherited metabolic defects of gluconeogenesis, pyruvate oxidation, the Krebs cycle, or the respiratory chain

A study showed that ferroptosis initiated APAP-induced liver injury, and ferroptosis inhibitors, such as ferrostatin-1 and iron chelator deferoxamine, alleviated APAP-induced liver injury ( + T cells by inhibiting ferroptosis ( Chronic liver injury refers to long-term and chronic damage to liver function caused by multiple factors, and it is mainly seen in chronic viral hepatitis, long-term heavy drinking, and fatty liver

The brain ranks high in this hierarchy, being able to maintain relatively high selenoprotein expression under Se deficiency (Solovyev, 2015

All participants followed a calorie-restricted diet (~300 kcal/day deficit)