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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

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Limitations of Available Evidence Research varies based on study design, dosing, and delivery method

Int J Mol Sci 24(13):10631 Guven L et al (2023) Phenolic compounds of Phlomis tuberosa by LCMS/MS-determination of antioxidant activity, molecular docking, and enzyme inhibition profiles