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This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

While the effect of diet and environmental exposures on the human microbiome and the implications of these changes on the host immune and inflammatory systems have been explored in AMD 115 , to gain a complete understanding of the complex interactions and their role in the pathogenesis and progression of dry AMD, all individual perturbations must be integrated into the entire system to establish a causal role