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It is known that Wnt/-catenin signaling has a developmental stage-specific biphasic effect on the cardiomyogenesis of mouse embryonic stem cells

Among gut microbiota-derived metabolites, bacterial tryptophan metabolites such as indole-3-propionic acid (IPA) can improve intestinal barrier function and insulin sensitivity through activation of the aryl hydrocarbon receptor (AhR) (14)

Methods: Patients eligible for PEDFIC 1 (NCT03566238) and PEDFIC 2 (NCT03659916) had elevated serum bile acids and significant pruritus at screening