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Additionally, none of these models recapitulates the three-dimensional (3D) bile canaliculus structures (thin and elongated lumina) observed in tissue 16 , making it difficult to model complex disease states or recapitulate patient-specific traits, both of which are essential for precision medicine and early diagnosis

Use of the solid oral pharmaceutical composition according to any one of items 1 to 56 for the manufacture of a medicament for the treatment or prevention of diabetes, obesity, nonalcoholic fatty liver disease, non-alcoholic steatohepatitis (NASH) or a cardiovascular disease

Participants who received GM1 also scored better on functional assessments than those who received a placebo