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Traditionally, farmed animals would have got their B12 from water and eating food from the ground but with so many now confined in factory farms, animals themselves are given B12 supplements

Verhoef et al, 1997b

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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)