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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

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However, when combined with insulin or sulfonylureas, dose reduction of these agents may be necessary [6]

doi: 10.1016/j.eurpsy.2017.03.002 63 GhadirivasfiM.NohesaraS.AhmadkhanihaH