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Fecal microbiota transplantation is a promising therapy for kidney diseases

While O 2 released into the mitochondrial matrix is directly converted by SOD2 into the less reactive H 2 O 2 , O 2 released by the complex III into the mitochondrial intermembrane space can be exported via voltage-dependent anion channels (VDAC) into the cytosol followed by a SOD1-mediated conversion into H 2 O 2 [6, 7]

Furthermore, NETs can activate the complement system, exacerbate endothelial damage and promote platelet activation

Mol Brain 5:35 [DOI] [PMC free article] [PubMed] [Google Scholar] 82.Oosterveen T, Garo P, Moles-Garcia E, Soleilhavoup C, Travaglio M, Sheraz S, Peltrini R, Patrick K, Labas V, Combes-Soia L et al (2021) Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinsons disease