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If a claim implies systemic benefits, treat it as a higher-uncertainty category and prioritise evidence quality over confidence

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44 Significantly higher glutathione peroxidase activity has been reported in a group of patients with SLE who tested positive for anticardiolipin and in patients with SLE whose Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores were higher than 3, compared to patients with SLEDAI less than 3