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This is particularly intriguing, as the recent work uncovered that U1-snRNP may serve as a governing machinery for blocking premature polyadenylation 48 , suggesting FUS/TLS might play an important role in regulating polyadenylation selection

4.13.2 Mechanical stress Mechanical testing demonstrates increased tissue stiffness that limits adipocyte expansion and triggers mechanotransduction through focal adhesion complexes (327, 328)

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These increase methylation demand and interfere with folate metabolism