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Overall, the findings of this study suggest that the impact of the ketogenic diet on tumor growth is influenced by the type of dietary fat consumed, particularly saturated fatty acids, which, when abundant in the ketogenic diet, can decrease SCD activity and further inhibit tumor growth [91]

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The interaction between hypoxia and mitochondria through the -ketoglutarate-dependent dioxygenase family suggests that interventions targeting this family could potentially prevent hypoxia-induced damage to mitochondria (Figure 1)

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