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These limitations collectively lead to transient and unpredictable therapeutic effects, underscoring the need for mechanistic clarification and technological innovation before mitochondrial transplantation can advance toward clinical application

For the ARISTOTLE trial population (apixaban for AF), the dose-reduction criteria require 2.5 mg twice daily when two or more of the following are present: age 80 years or older, body weight 60 kg or less, or serum creatinine 1.5 mg/dL or higher (Granger et al., NEJM 2011) [3]

The math should be written before mixing, not after

Among adults aged 2064 years, the number of deaths attributable to alcohol has risen in recent years