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This is an interesting point when you consider that in prostate cancer it has been shown that estrogen can substitute to upregulate IGF-1R when androgen levels are low (Turcu et al., 2017)

Proprits antioxydante et anti-inflammatoire Rle dtoxifiant: limination des toxines Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK, Lee ZW (2005)

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These changes effectively increase the stability of Mod GRF during storage, transportation, and administration while enhancing its affinity for the GHRH receptor