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However, the ZFTF gene expression level in the transformant ZFTF-3 strain is not further increased under the MT-treatment condition, indicating that the Padh4 promoter is not inducible by MT treatment (Figure 5D)

Although the absolute gains were limited, the findings suggest a potential clinical benefit of the CGS regimen, warranting further investigation in specific patient subgroups

HBP activity exerts context-dependent effects: acute activation may offer cardioprotection, whereas chronic HBP upregulation under hyperglycemia induces endoplasmic reticular (ER) stress, lipid accumulation, and inflammation [72]

1.5.6) 66 , which specifies and samples all rotatable bonds and computes partial charges for the substrate structures