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Unlike other bacteria, Mtb has only one fumarase (Rv1098c), making it a vulnerable and attractive therapeutic target for drug development against Mtb [8, 223, 286]

Psychopharmacology 237 , 27392752 (2020)

This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)