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BER enzymes are primarily targeted at removing N7-MeG and N3-MeA lesions, subsequently repairing the DNA through the collaborative action of DNA polymerase and DNA ligase, thus restoring the DNA strand to its original, non-damaged state [165]

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Viral or bacterial cross-infections, especially in early life, which may occur more frequently in larger families, have been discussed to have a protective role against atopic disease by preventing proliferation of Th2-lymphocytes (Romagnani, 1992b