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10.1016/j.bioactmat.2021.09.035 64 JiaoL.LiuY.YuX

The firefly and Renilla luciferase activities were measured using the Dual-Luciferase Reporter Assay System (Promega)

Disrupted iron regulation in the brain and periphery in cocaine addiction

mg/day of vitamin B6 is adequate for good health in most people, yet some individuals Factors that cause nutritional needs to vary from per- with inherited defects in vitamin B6 metabol- son to person ism need up to 30 to 100 times this amount.25 The absorption and daily requirement for cal- Genetic differences Growth during child- cium can vary four- to fivefold among healthy (biochemical indi- hood and adoles- middle-aged women.26 Normal plasma con- viduality) cence, aging centrations for 1,25 (OH)2 vitamin D (the acti- vated form of the vitamin) vary between 15 Pregnancy and Gender and 45 pg/ml in healthy adults