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It can be caused by a variety of factors including chronic hepatitis, autoimmune disorders, alcohol-related liver disease, non-alcoholic liver diseases, and other conditions

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Mod Pathol 20(1):7683 Mousa SA et al (2007) Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds

Consequently, efficacy observed in these systems should primarily be interpreted as proof of biological plausibility and mechanism, rather than as a direct surrogate of clinical efficacy