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Some small human trials mostly in PBC and insulin resistance show encouraging results, while larger, more definitive studies are still missing.4 6 In other areas, like amyotrophic lateral sclerosis (ALS) and neuroprotection, the story is even less clear: despite promising preclinical data, a recent Phase 3 ALS trial failed to confirm meaningful benefit.23 24 To help make sense of this, weve summarized the potential benefits of TUDCA in the chart below

Bowcock AM

The GPCR family is exceptionally important clinically, as demonstrated by the fact that 35% of FDA-approved drugs target GPCRs or elements of their down-stream signaling pathways

There are other natural complexing agents such as rhodotorulic acid, the metabolite of Streptomyces deferoxamine, and marine shrubs also has weak copper excretion ability