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Since AlphaFold generates single ranked structures, rather than conformational ensembles, it cannot elucidate the mechanisms of allosteric activating driver hotspot mutations nor of allosteric drug resistance

10.1016/j.phrs.2021.105542 91 WangH

However, this alternative approach would substantially increase the computational costs for both training and inference

Nerve growth factor was the first neurotrophic factor to be discovered and is widely used in China to promote nerve repair and regeneration in a range of neurological conditions, including Bells palsy