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Chromosomal rearrangements, mitotic recombination, point mutations, and epigenetic events like promoter methylation can inactivate tumour suppressor genes [309]

Compounds such as Britanin have shown promise in preclinical studies for their ability to modulate angiogenesis and inhibit tumor growth in various gastrointestinal cancers ( In conclusion, targeting angiogenesis presents a multifaceted approach to the treatment of gastrointestinal tumors

Broadly, a similar distribution pattern is supported over time, sustaining the direction from the South toward the East as the axis from the highest concentration, while the North and West areas harbor those lowest ones