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[DOI] [PMC free article] [PubMed] [Google Scholar] 188.Miao L, Liu Q, Lin CM, Luo C, Wang Y, Liu L, Yin W, Hu S, Kim WY, Huang L

This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

This shift resembles the adaptive metabolic response observed during caloric restriction or fasting, where anabolic pathways are suppressed and catabolic processes are enhanced to maintain energy homeostasis and preserve mitochondrial function under nutrient-limited conditions

That number alone tells your doctor almost nothing about whether your therapy is actually safe, effective, or sustainable long-term