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Springer, pp 105137 Uruno A, Yamamoto M (2023) The KEAP1-NRF2 system and neurodegenerative diseases

Figure 1 NAD + Treatment Enhances the GSH/GSSG Ratio and Total Glutathione Levels by Increasing Both GCL Levels and Nrf2 Activity of PC12 Cells GCL is the key enzyme for GSH synthesis (Dickinson and Forman, + treatment can increase the total glutathione levels has suggested that the GCL activity may be increased in the NAD + -treated cells