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Predictors of severe Crohns disease

Mulla, M.H

SQSTM1 is known as an ubiquitin-binding protein and promotes the aggregation of cullin3-modified caspase-8 within p62-dependent foci, leading to cell apoptosis 50

Mechanisms of resistance to, and toxicities resulting from, IGF-1R-targeted drugs are well-catalogued, and there is general appreciation of the fact that a lack of biomarker-based patient stratification was a limitation of previous clinical trials