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Based on their primary mechanisms and therapeutic actions, natural products can be broadly classified into the following categories

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H 2 S 2 , H 2 S 3 and H 2 S

In fact, a key parameter omitted in the trials with deferiprone was that the iron chelator was not targeted to the mitochondria, so effectively only a small fraction of the compound delivered would accumulate in the principal site of damage under these conditions

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics