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J Biol Inorg Chem

High-dose transdermal nicotine in Parkinson's disease patients: a randomized, open-label, blinded-endpoint evaluation phase 2 study

However, the high prevalence of VD deficiency in PD patients could also be the result of reduced outdoor activity owing to activity restriction, and the possibility that gastrointestinal dysfunction (a non-motor PD symptom) leads to lower VD2 levels in PD patients cannot be completely ruled out