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Liu Y, Li J, Xu J, Long Y, Wang Y, Liu X, et al

Through the SH2 domain in the receptor, IGF-IR binds to the SH2 domain of Grb2, which, in turn, complexes with Sos, a guanine nucleotide exchange factor that mediates GDP/GTP exchange in Ras GTPase, and leads to Ras activation

Since this process also appears to be regulated via a negative feedback mechanism, the ancillary impacts typically associated with excessive growth hormone production appear to be avoided