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# The Orange Book was initially intended as a resource to provide medical professionals with a list of approved drugs and their corresponding therapeutic equivalents

Moreover, a 5-week feeding regimen was found to be more suitable than the initial 6-week regimen for the acute demyelination model, since demyelination in the corpus callosum had already peaked/completed at this time point, and detectable remyelination was observed at 6 weeks even under the continuous feeding of CPZ (Matsushima and Morell, 2001