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Administered intramuscularly (usually in the upper arm or buttocks), these injections deliver a high dose of either Vitamin D2 (ergocalciferol) or Vitamin D3 (cholecalciferol)

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

This review highlights that NAD+ levels decline with age and play a critical role in metabolic and cellular health, with supplementation shown to raise NAD+ levels and potentially combat aspects of age-related decline