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Introduction Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by the presence of non-caseating granulomas in affected organs ( None of the drugs currently used for sarcoidosis treatment have been rigorously studied in large randomized controlled trials (RCTs) ( The recently published European Respiratory Society (ERS) clinical practice guidelines help to address these concerns by outlining tentative treatment approaches for various organ manifestations of sarcoidosis ( Current advancements in personalized and precision medicine as well as the introduction of compounds developed specifically for sarcoidosis treatment, underscore the imperative of standardized elements of clinical trial design in either collective or organ-specific sarcoidosis

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Some studies have shown an increased risk of depression and cognitive disorders in individuals with T2D taking metformin and vitamin B12 deficiency [61,62]

In previous studies, p53 TAD was shown to significantly influence the DNA selectivity of p53 DBD, with the acidic residues of TAD believed to contribute to this selectivity through interactions with the basic residues of DBD 54