glutathione peroxidase v. the kinetic mechanism Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities Kinetic Study of the Reaction

Of the records screened, 46 studies were excluded as they were non-clinical studies (including reviews, editorials, and or conference abstracts), 121 studies were excluded because those studies involved non-human subjects, 28 studies were excluded as they were not conducted in AD or MCI patients, 1 study was excluded as it did not have a healthy control group, and 14 studies were excluded as they did not measure GSH in the brain

What is an Antioxidant

The antioxidant characteristic of N-acetylcysteine has been ascribable to its reactivity with OH, CO 3 , NO 2 , and thiyl radicals, the ability to repair oxidative damaged key cellular molecules, and activity as a precursor for biosynthesis of glutathione

Interestingly, loss of FH also triggered a compensatory rise in GSH levels by upregulation of cystine transport SLC7A11 expression and increases in cystine uptake and glutaminolysis-dependent GSH biosynthesis (121)