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Medication Management Joel Young, MD, RCBM's medical director and founder, has authored the book Understanding and Treating Chronic Fatigue: A Practical Guide for Patients, Families, and Practitioners

H 2 S and NO Hybrid Synthetic Donor It is synthesized from S-(prop-2-yn-1-yl)-L-cysteine by reaction with di-tert-butyl dicarbonate and subsequent reaction of N-(tert-butoxycarbonyl)-S-(prop-2-yn-1-yl)-L-cysteine with 3-(hydroxymethyl)-4-phenyl-1,2,5-oxadiazole 2-oxide (Figure 48)

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

If you are considering switching due to plateau, exploring why you are not losing weight on your current medication may reveal other factors at play