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In fact, the NAD + glycohydrolase activity of CD38 was essential for tumor progression by downregulating tumor suppressors (such as KEAP1) and upregulating oncogenes (such as NRF2) [46]

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[142] Identification of liver as an anti-anemia food [edit] During the 1920s, George Whipple discovered that ingesting large amounts of raw liver seemed to most rapidly cure the anemia of blood loss in dogs, and hypothesized that eating liver might treat pernicious anemia