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Researchers can explore pathways involving the expression of Brain-Derived Neurotrophic Factor (BDNF) and the regulation of cytokine activity

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Major factors contributing to the noncovalent recognition of small molecules by proteins and the binding strength between them include: Van der Waals forces, hydrogen bonds, ionic bonds, molecular reorganization, desolvation energy of the small molecule, hydrophobic interactions and, in certain instances, displacement energy for pre-existing bound ligands