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Hence, a possible adipo-insular axis is reasonable, where the IGF system may play a significant role (43)

Table 2 summarizes the main types of LSDs that invade the CNS according to the accumulated general substrate

Finally, ceramide can follow four major catabolic pathways: (1) phosphorylated by the ceramide kinase (CERK) to form ceramide-1-phosphate (C1P), (2) incorporated into sphingomyelin-by-sphingomyelin synthase (SMS) activity, (3) or into glucosylceramide by the activation of glucosylceramide synthases (GCS), leading to the generation of complex SLs like cerebrosides, gangliosides, sulfatides and globosides

It also provides you a fairer, glowing, healthy and younger skin