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doi: 10.1111/imm.13462 57 KimDHLeeW-W

There were no statistically significant differences in the parameters, neither between the experimental and control groups, nor between the initial baseline (T1) and final measurements (T4)

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This was first explored by Balthasar and colleagues, who in 2005 proved that specific inhibition of the IgG:FcRn interaction by use of a murine mAb (mouse IgG1, clone 4C9) with V regions specific for rat 2m generated by Bjorkman and colleagues could deplete endogenous IgG levels in rats [113, 114]