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JCI Insight (2017) 2(7):e90777

Pathways for small molecule delivery to the central nervous system across the bloodbrain barrier

Overall, the GHGHRIGF1 axis, part of the somatotropichypothalamicpituitary axis, has been commonly recognized in response to somatic growth, including cell proliferation, differentiation, division, and survival (Figure 1)

A meta-analysis including five randomized controlled trials (RCTs) and ten prospective non-RCTs statistically demonstrated the benefits of selenium supplementation in preventing KBD in children 75