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Allele frequencies for genetic polymorphism are such that ~1 in 300 Caucasians is homozygous for a defective allele or alleles for the trait of very low activity, ~11% of people are heterozygous and have intermediate activity

Melatonin has an easier access to subcellular organelles such as the mitochondria, the primary sites for ROS production due to their lipophilic and hydrophilic characteristics (Reiter et al., 2003

The mechanism suggested by Stenuit et al

The assay was performed on a GenomeLab GeXP genetic analysis system (AB SCIEX, USA) using capillary electrophoresis, with results interpreted by the system's built-in software in accordance with standard operating procedures