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Risk increases significantly after 2+ years of use Post-bariatric surgery patients gastric bypass removes or bypasses the sites of intrinsic factor production and B12 absorption People with autoimmune conditions pernicious anemia (anti-intrinsic factor antibodies) and autoimmune gastritis directly block absorption People with GI conditions Crohns disease (especially ileal involvement), celiac disease, SIBO, and chronic H

The following table represents the RNI for the different age groups

Hepatology 66 , 324334 (2017)

For reconstitution, the standard solvent in published protocols is bacteriostatic or sterile water