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For instance, PRE084, an agonist of the Sigma-1 receptor, Sig-1R, an ER resident chaperone protein, increases NF-B expression and improves cell viability and mitigates the toxicity mediated by mutant huntingtin proteins in neuronal PC6.3 cells (Hyrskyluoto et al., 2013)

doi: 10.3389/fnins.2025.1576773 Received 14 February 2025 Accepted 08 April 2025 Published 23 April 2025 Volume 19 - 2025 Edited by Matilde Otero-Losada, National Scientific and Technical Research Council (CONICET), Argentina Reviewed by Lefteris Zacharia, University of Nicosia, Cyprus Da Sun, Wenzhou University, China Shubham Upadhayay, Central University of Punjab, India Updates Copyright 2025 Wang, Zhang and Zhai

177 Low-dose naltrexone has been hypothesized to work by reducing neuroinflammation, modulating the bodys own opioid system, and modulating neuroimmune function

Lederer, Mitochondrial calcium and the regulation of metabolism in the heart