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The rationale for this strategy lies in both the physiological profile of oxytocin and clinical observations indicating lower circulating oxytocin levels in children with ASD compared to neurotypical individuals

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Cynaroside interventions significantly inhibited a variety of cytokines and related receptors involved in the inflammatory pathway, the chemokines and their receptors that were downregulated included C-C motif ligand (CCL)1-3, CCL19, CCL21, C-C motif receptor (CCR)7, CCR8, C-X-C motif chemokine ligand (CXCL)2, CXCL8, CXCL9 and CXCL12