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J Assoc Physicians India 72(9):32-36, 2024

Furthermore, SSP upregulation in some studies may be associated with global metabolic reprogramming in tumor cells, rather than directly driving resistance (138, 139)

Pancreatic stellate cell-derived alanine also acts as an alternative carbon source to fuel the tricarboxylic acid (TCA) cycle in pancreatic ductal adenocarcinoma cells [31]

For example, the folding of N-myristoylated G subunits of heterotrimeric G-proteins (~ 355 aa) requires the dedicated chaperone Ric-8A, which binds partially folded G, keeps the the N-myristate solvent-protected and only releases it upon client activation (via nucleotide binding) 47,48