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E-mail: [email protected] Date of Received: 28-12-2010 Date of Accepted: 06-06-2011 Available Online: 15-08-2011 Abstract The primary role of glutathione transferase is to defend an organism from toxicities through catalyzing the reaction of glutathione (GSH) with potentially toxic compounds or metabolites to their chemically and biologically inert conju-gates

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Their null status has documented associations in the research literature with differential response to environmental exposures, medication metabolism, and oxidative stress burden across multiple biological systems

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In addition, the nanovaccine Si9GM is made of central radial mesoporous silica nanoparticles coated with membranes from bone marrow-derived dendritic cells (BMDCs) expressing antigen peptides, used to deliver CLEC9A-antigen conjugates and STING agonists (23-cGAMP), which can selectively target cDC1, promote DCs maturation, and lead to upregulation of cytotoxic T cells, reduction of Tregs, and M1/M2 macrophage polarization and can induce strong tumor growth and metastasis inhibition when combined with PD-1 blockade (224)

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