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5 Our previous study had revealed that this quantitative expansion is accompanied by the functional activation of neutrophils, characterized by enhanced release of reactive oxygen species (ROS), increased formation of neutrophil extracellular traps (NETs), and elevated secretion of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-)

A notable observation was the emergence of small, round colonies with a lumen forming in the centre following 2% DMSO treatment consistent with previous reports [45]

[14] In the hepatocyte , this oxidation is favored by the low NADH/NAD + ratio in the cytosol

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