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Outcomes covered biologic/surrogate (e.g., proteinuria, estimated glomerular filtration rate [eGFR] slope) and hard endpoints (kidney failure, major cardiovascular events, fractures, mortality)

To prevent premature peripheral decarboxylation of LD, which necessitates higher dosing and increases the risk of side effects, it is co-administered with CD, a peripheral decarboxylase inhibitor

Regular Exercise Physical activity can enhance the effects of B12 on energy levels and mood

111 Furthermore, diabetes disrupts brain iron homeostasis, leading to neurotoxicity through inflammation, increased BBB permeability, altered iron ion redistribution, and impaired iron metabolism