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The requirement of aspartate for maximum glutamate synthesis indicates that glutamate synthesis from -ketoglutarate probably occurs by transamination, and pathway models for interaction between biosynthesis and oxidative degradation of both glutamate and GABA suggest that transamination may also be the default reaction for initiation of glutamate oxidation

doi: 10.1038/nchembio.1416 48 GreenDR

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Additionally, adenosine triphosphate (ATP) released from ferroptotic cells activates the NLRP3 inflammasome, leading to caspase-1 activation and maturation of IL-1 and IL-18 (119)